No, that option is not enabled.

It happens approximately twice a day.

Yes, with 2.13 it still happens.

A quick reload of Fastkey (rightclick - Reload) resolves the issue though.

If you mean with "show mouse trail" the option in Control Panel - Mouse - Display Pointer Trails: that one's not activated.

I'm having the same issue as well. Happens to all my mouses (Logitech Performance MX, uninstalled all Logitech drivers & SW, still happens), also with Dell Touchpad (Alps driver), doesn't scroll anymore. Interestingly, holding down Alt makes scrolling work again, but when releasing Alt scrolling...